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Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage

Zhen Xu,Shuping Qiao, Wei Qian,Yanan Zhu,Wenyue Yan,Sunan Shen,Tingting Wang

International Immunopharmacology（2022）

Cited 3|Views5
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Abstract
•Card9-/- mice have increased susceptibility to fungal peritonitis compared to wild-type mice.•Card9-deficient macrophages exhibit impaired activation of autophagy upon zymosan treatment.•Card9 activates autophagy in macrophages through Malt1.•Malt1 attenuates P62 accumulation by binding to P62.
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Key words
Peritonitis,Card9,Malt1,Autophagy,Macrophage
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