Development and validation of a paper spray mass spectrometry method for the rapid quantitation of remdesivir and its active metabolite, GS-441524, in human plasma

Christine Skaggs,Hannah Zimmerman,Nicholas Manicke,Lindsey Kirkpatrick

Journal of Mass Spectrometry and Advances in the Clinical Lab（2022）

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摘要

•Rapid PS-MS/MS quantification of remdesivir and its active metabolite, GS-441524, directly from plasma.•No sample preparation, short turn-around time, use of stable isotope-labeled internal standards.•Robust stability data are presented.•Suitable for adjusting remdesivir dosage for optimal efficacy and minimal toxicity.

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关键词

ANOVA,AUC,CE,CES1,CES2,R2,CV,DMSO,EC50,ECMO,H-ESI,Inc,IRB,IS,kV,LC-MS/MS,LLC,LOD,LLOQ,m/z,µg,µL,mL,MP,ng,PS-MS/MS,PK,PD,RF,S/B,SS,SIL,therapeutic drug monitoring,QC,QC-LLOQ,V

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