[Mediating effect of adulthood BMI/waist circumference on correlation between juvenile BMI/waist circumference and adulthood blood pressure].

OBJECTIVE:To analyze the relationship between juvenile body mass index(BMI)/waist circumference(WC) and adult blood pressure(BP), and to further explore the mediating role of adult BMI/WC in this association.\nMETHODS:Based on the data of China Health and Nutrition Survey(CHNS) from 1993 to 2015, 1313 subjects were selected, who participated in the survey both in juvenile(6-17 years old) and adult(18-35 years old). The mediating effect model was used to analyze the effect of adult BMI/WC in the association between juvenile BMI/WC and adult BP.\nRESULTS:There was a positive correlation between juvenile BMI/WC and adult systolic blood pressure [β(SE)_(adjusted)=0.10(0.03)/0.08(0.03)] and diastolic blood pressure [β(SE)_(adjusted)=0.13(0.03)/0.08(0.03)] with P <0.01. Adult BMI/WC played partial mediating effect in the association between juvenile BMI/WC and adult systolic blood pressure and diastolic blood pressure: the percentage of mediating effect of BMI were 70.00%(95%CI 42.68%-73.33%)for SBP and 23.08%(95%CI 14.29%-26.32%) for DBP, the percentage of mediating effect of WC were 37.50%(95%CI 20.00%-41.67%)for SBP and 25.00%(95%CI 20.00%-35.71%) for DBP, respectively.\nCONCLUSION:There is a positive correlation between juvenile BMI/WC and adult BP, and adult BMI/WC might mediate the effect of juvenile BMI and WC on adult BP.