老年瓣膜病心房颤动射频消融病人IL-6、NT-proBNP水平变化及临床意义
Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease(2022)
Abstract
目的 观察老年瓣膜病心房颤动病人外科射频消融术效果及手术前后白细胞介素-6(IL-6)和氨基末端脑利钠肽原(NT-proBNP)水平的变化,探讨二者与手术效果的关系.方法 选取老年瓣膜病合并心房颤动病人116例,按治疗方式分为观察组与对照组.观察组60例,行瓣膜置换与射频消融术;对照组56例,行瓣膜置换术.观察两组手术效果和IL-6、NT-proBNP水平变化.结果 观察组较对照组有更高的窦性转复率.观察组出院前和出院6个月血浆中IL-6和NT-proBNP水平明显低于对照组(P<0.05).出院前和出院6个月病人窦性亚组血浆IL-6和NT-proBNP水平明显低于心房颤动亚组(P<0.05).结论 射频消融术能够提高老年瓣膜病心房颤动病人窦性转复率,降低血浆IL-6和NT-proBNP水平,而低水平的IL-6和NT-proBNP有助于窦性心律的维持.
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