Down-regulating of MFN2 promotes vascular calcification via regulating RAS-RAF-ERK1/2 pathway

Wen-Bo Zhang,Si-Yi Feng,Zhan-Xiang Xiao,You-Fei Qi,Zhao-Fan Zeng,Hao Chen

International Journal of Cardiology（2022）

引用 3|浏览4

暂无评分

摘要

•MFN2 is down-regulated in AS mice and patients.•MFN2 depletion drives VSMC chondrocyte differentiation and consequent calcification.•MFN2 silencing promotes VC in atherosclerotic mice.•E2F1 promotes the transcription and expression of MFN2 in VSMCs.•RAS-RAF-ERK1/2 pathway involves in MFN2-mediated VSMC calcification.

查看译文

关键词

Vascular calcification,MFN2,Atherosclerosis,RAS-RAF-ERK1/2 pathway,Vascular smooth muscle cells

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要