Methylation of the Hippo effector YAP by the methyltransferase SETD7 drives myocardial ischaemic injury: a translational study.

Cardiovascular research（2023）

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摘要

We show a methylation-dependent checkpoint regulating oxidative stress during myocardial ischaemia. SETD7 inhibition may represent a valid therapeutic strategy in this setting.

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关键词

Hippo pathway,Ischaemic heart disease,Myocardial infarction,Oxidative stress,Protein methylation

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