Granulocyte-macrophage colony-stimulating factor-triggered innate immune tolerance against chronic stress-induced behavioral abnormalities in mice

•GM-CSF preconditioning prevents CSDS-induced depression-like behaviors.•GM-CSF preconditioning prevents CSDS-induced anxiety-like behaviors.•GM-CSF preconditioning prevents the neuroinflammatory responses in CSDS mice.•Minocycline abrogates the effect of GM-CSF on CSDS-induced abnormal behaviors.•Minocycline abrogates the effect of GM-CSF on neuroinflammation in CSDS mice.