Altemicidin

(−)-Altemicidin is an interesting naturally occurring 6-azainden monoterpene sulfonamide alkaloid that exhibits strong inhibition against tumor cells and has potent acaricidal activity. (−)-Altemicidin 1 was isolated by Takahashi research group in 1989 from the actinomycete strain Streptomyces sioyaensis. The acylated structure of the altemicidin showed strong inhibitory activity against isoleucyl, leucyl, and valyl tRNA synthetase. The interesting biological properties and complex structural features of (−)-altemicidin make it an attractive target for synthetic organic chemists.