Collagen-based nanomaterials in drug delivery and biomedical applications

In this chapter, we aim to summarize the recent advancements in developing collagen-based nanoparticles as drug carriers and their biomedical applications. A paradigm shift has taken place in the field of nanotechnology due to the use of protein-based drug delivery systems. Collagen is the most abundant protein and the primary structural component of connective tissues in the body is being assessed for its unique properties like biocompatibility, biodegradability, low antigenicity, and ease of fabrication of nanoparticles making it the most cost-effective protein-polymer available for drug delivery. The structural elucidation of the collagen molecule has fundamentally formed the basis for its unique physicochemical properties and stability of the molecule. Significant research has suggested no toxicity issues associated with the delivery of collagen-based nanoparticles. In addition, various fabrication techniques for collagen-based nanoparticles are also discussed in the chapter.