Periferik sinir üzerinde topikal uygulanan vancomisin toz perinöral fibrozise neden olur mu?

Purpose: The aim of this experimental rat study is to investigate whether vancomycin powder directly and topically applied on the sciatic nerve causes perineural fibrosis and chronic inflammation development. Materials and Methods: Thirty young adult male Wistar-Albino rats were included in the study and divided into 3 groups of 10 rats based on the dose to be applied after intraperitoneal anesthesia. After the sciatic nerve exploration, 10 rats (group 1) were administered a single dose of vancomycin powder, 10 rats (group 2) were administered a double dose of vancomycin, and control group was created with 10 animals which were administered no medication (group 3). After 3 weeks, rats were sacrificed, tissue samples were taken around sciatic nerve and sent for histopathological examination. Results: Grade 1 perineural fibrosis was detected in 1 animal (10%) in group 1. Grade 2 perineural fibrosis was detected in 1 animal (10%) and grade 1 perineural fibrosis was detected in 1 of 10 animals (10%) in group 2. In Group 3, grade 1 perineural fibrosis was detected in 1 experimental animal (10%). Chronic inflammation was not detected in any experimental animal. No significant difference was found between the 3 groups in terms of perineural fibrosis (p=0.753). Conclusion: In this experimental animal study, we found that fibrosis development did not differ significantly among the groups. We believe that more objective results can be obtained as a result of experimental studies with larger participation and more detailed histopathological examinations.