Photosensitizers Based on Carborane Conjugates of Meso-Arylporphyrins/Chlorins and Dipyrromethenes for Photodynamic and Boron Neutron Capture Therapies

The present review highlights the state-of-the-art in the synthesis of carborane derivatives of meso-arylporphyrins/chlorins and dipyrromethenes (BODIPY) for the application in photodynamic and boron neutron capture therapies of cancer. The main methods for the functionalization of porphyrins/chlorins and BODIPYs by boron polyhedra and the approaches to optimization of the properties of these compounds as antitumor agents are considered. The results of investigations on the photophysical and biological properties of carboranyl-containing porphyrins/chlorins and BODIPYs are presented.