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Pharmacological studies on pulmonary fibrosis model induced by intratracheal instillation of bleomycin in mice

Jun-ichi Fuchikami,Maki Takahashi,Yoshiyuki Suzuki,Atsuko Ichikawa,Yasuki Akie,Hiroyuki Nakamura

Proceedings for Annual Meeting of The Japanese Pharmacological Society（2021）

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Abstract
Idiopathic pulmonary fibrosis (IPF) is one of the most aggressive interstitial lung diseases characterized by a chronic and progressive course leading to respiratory failure. The effects of nintedanib (NTB) and pirfenidone (PIR) on the changes in respiratory function, lung hydroxyproline (Hyp) levels, and lung tissue were examined with the pulmonary fibrosis model induced by bleomycin (BLM) in mice.
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Key words
pulmonary fibrosis model,bleomycin,pharmacological studies
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