Structure prediction of the N-terminal regulatory domain of the human tryptophan hydroxylase 2

Masanori Ootaki,Tomoko Hiroi,Yuki Ohta,Yuko Takeba,Keisuke Kida,Hiroaki Matsui,Naoki Matsumoto

Proceedings for Annual Meeting of The Japanese Pharmacological Society（2021）

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Abstract

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin biosynthesis and exists as two isoforms, TPH1 and TPH2. In the central nervous system, TPH2 is the predominant isoform and is exclusively expressed. TPH2 has an N-terminal regulatory domain (NRD) (amino acids 2 - 44) that is thought to repress its own synthesis, while TPH1 lacks NRD.

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Key words

human tryptophan hydroxylase,n-terminal

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