Effect of Gpnmb gene on memory deficits in 9 month-old 5xFAD mice
Proceedings for Annual Meeting of The Japanese Pharmacological Society(2021)
摘要
The onset and progression of Alzheimer's disease (AD) correlate with neuroinflammatory processes, and inflammatory microglia (MG) are associated with AD-like pathology in a transgenic mouse model. GPNMB was identified as a marker for one subtype (type 1) of rat primary MG (Kawahara et al., GLIA, 2016). However, the function of GPNMB+ type 1 MG in AD brain are largely unknown. We recently reported that memory deficits in 9 month-old APP23 mice, one of the amyloid precursor protein transgenic mice, was reduced in Gpnmb gene heterozygosity (APP23;Gpnmb+/-, 92ndAnnual meeting of the Japanese Pharmacological Society, 2-O-04, 2019). In the present study, we investigated whether Gpnmb gene heterozygosity could affect on memory deficits in 9-month old 5xFAD mice, other AD model mice. We used 5xFAD mice backcrossed to C57BL/6J mice at least for ten generation. Spatial learning and memory was evaluated by Morris Water Maze test. We observed that the number of Nissl-positive neurons in subiculum of 5xFAD mice were lower than those in their wild type littermates. We observed that AD-related memory deficits in 9 month-old 5xFAD mice were decreased in Gpnmb gene heterozygosity (5xFAD;Gpnmb+/-). These finding suggest that GPNMB-positive type 1 MG may be related to memory deficits in AD.
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关键词
gpnmb gene,memory deficits,mice,month-old
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