Automatic Embedding Technique for Histopathological Examination Increases R0 Resection Rates for Endoscopic Submucosal Dissection: A Major Impact in Decreasing Local Risk Status for Anorectal Cases

Aims Endoscopic submucosal dissection (ESD) allows « en-bloc » resection of superficial gastrointestinal neoplasia. Standardized macroscopic and microscopic approaches are required to adequately assess the curative status. Nevertheless, margin assessment is sometimes challenging especially if samples are not correctly orientated within paraffin blocks.The aim of the study was to compare margin status of ESD specimens embedded using one of two methods: a manual embedding technique (MET) or an automatic embedding technique (AET).