Hypertension Gene Risk Score in Diagnosis and Prediction of Complications

Hypertension (HT) is a polygenic disease and is the most important risk factor for morbidity and mortality globally due to associated risk of cardiovascular diseases (CVD). The relation between genetic determinants of hypertension and the development of CVD can therefore be important for understanding disease mechanisms. This review aims to highlight the potential of genomic screening to develop and evaluate a gene risk score for cardiovascular risk prediction in hypertension. Gene risk score as a risk prediction tool is a promising area potentially supporting effective prevention of HT and CVD. Generating a gene risk score substantially improves health outcomes by diagnosing the risk of developing a disease, based on the total number of changes related to disease, followed by early and aggressive intervention in patients with high score