Deletion of Kir5.1 abolishes the effect of high Na⁺ intake on Kir4.1 and Na⁺-Cl⁻ cotransporter

Xin-Peng Duan,Peng Wu,Dan-Dan Zhang,Zhong-Xiuzi Gao,Yu Xiao,Evan C. Ray,Wen-Hui Wang,Dao-Hong Lin

American Journal of Physiology-Renal Physiology（2021）

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摘要

Kir5.1 plays an important role in mediating the effect of high sodium intake on basolateral K+ channels in the distal convoluted tubule and Na+-Cl− cotransporter activity/expression.

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Deletion of Kir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl− cotransporter

Deletion of Kir5.1 abolishes the effect of high Na⁺ intake on Kir4.1 and Na⁺-Cl⁻ cotransporter