Detection of ibuprofen and aspirin on silver nets by surface enhanced Raman scattering (SERS) spectroscopy

Abstract In this work, surface enhanced Raman scattering (SERS) spectra of aspirin and ibuprofen molecules adsorbed on the surface of silver nets sputtered on porous silicon were collected and analyzed. The bands in the SERS-spectra were correlated in accordance with the type of molecular vibration. Predominantly chemical adsorption of the indicated drugs on the SERS-active substrate through oxygen was observed. It was established that the Raman spectroscopy combined with the SERS-active silver nets makes it possible to detect the aspirin and ibuprofen at 10-6 M concentration.