Comparison of REMS, NEWS, qSOFA scales and SIRS criteria in sepsis prediction for patients with confirmed SARS-CoV-2 infection: retrospective observational study

Introduction. Novel coronavirus disease is often accompanied by sepsis. This leads us to search of sepsis prediction tools. Objectives. Comparison of REMS, NEWS, qSOFA scales and SIRS criteria in sepsis prediction for patients with confirmed SARS-CoV-2 infection. Materials and methods. 167 medical cards retrospective analysis of patients with confirmed SARS-CoV-2 infection on admission to ICU. Results. In sepsis prediction only NEWS (0,819 [95% CI 0.738-0,884]) showed resolution high enough to serve as supplemental clinical information. REMS (0.798 [95% CI 0.715-0.866]), qSOFA (0.716 [95% CI 0.626-0.795]) and SIRS criteria (0.710 [95% CI 0.620-0.790]) showed insufficient resolution in sepsis prediction for patients with SARS-CoV-2. NEWS in pairwise comparison showed significantly better resolution than qSOFA (p = 0.002) and SIRS criteria (p = 0.013). All scales showed good calibration. Conclusions. Only NEWS scale showed good resolution and calibration and can be used as supplemental clinical information in sepsis prediction for patients with SARS-CoV-2 infection.