Biological activity and chemical composition of the ethanolic extracts of Miconia ferruginata DC. / Atividade biológica e composição química dos extratos etanólicos de Miconia ferruginata DC.

Ethnopharmacological relevance: Miconia ferruginata DC. is a native plant from Brazilian Cerrado biome known as “pixirica” or “babatenã”, widely used in traditional medicine as an anti-inflammatory and antibiotic agent. Aim of the study: This study aimed to perform a preliminary analysis of the chemical profile and screening of biological activities of the ethanolic extracts of the leaves/flowers (EELF) and of the stem (EES) of this species. Materials and methods: The techniques Ultra-Fast Liquid Chromatography with diode-array detection (UFLC-DAD) and High-Performance Liquid Chromatography with diode-array detection and mass spectrometry (HPLC-DAD-MS) performed chemical analysis. Biological activities evaluated for the antibacterial, antitripanosamatides and antitumor effect through in vitro assays, by MTT and resazurin. Results: Although the extracts showed a negligible result for antibacterial and antitripanosamatides effect, this species showed a high cytotoxicity against tumor cells ( p< 0.001) of 4T1, A549 and? MDA-MB-231, associated with low cell toxicity against fibroblasts. High concentration of phenolic compounds detected in the extracts, especially flavonoids derivates from quercetin, catechins and phenolic acids. Conclusion: These phenolic compounds have a high biological potential and may be responsible for the observed cytoxicity, together the data suggest the M. ferruginata has a great potential for being one promising candidate for further studies against cancer.