Effect of Grape Juice Ingestion on Plasma Inflammatory Biomarkers in Overweight and Insulin Resistance Women

Abstract Objectives To investigate the effect of grape juice ingestion in the inflammatory process in overweight and insulin resistance women. Methods An intervention study was conducted, in which, for 4 weeks, the volunteers ingested 500 mL of grape juice daily. Blood samples were collected at baseline and 2 and 4 weeks after the beginning of the grape juice ingestion. The study population consisted of healthy women (n = 20), aged between 18 and 40 years, and body mass index classified as overweight (25–29.9 kg/m²). Lipid profile and plasma glucose, insulin, leptin, adiponectin, inflammatory biomarkers (IL-10, IL-6, TNF-α, C-reactive protein, MCP-1, VCAM-1, and ICAM-1) levels were analyzed. Food consumption was evaluated by the analysis of three 24 hours recalls collected at all times. Results The intake of grape juice promoted a significant increased (P < 0.05) in plasma triacylglycerols levels after 4 weeks of ingestion in comparison to the baseline. The intervention with grape juice significantly reduced plasma sICAM-1 levels after 4 weeks in comparison to the baseline. Conclusions Grape juice reduced a biomarker related to endothelial dysfunction in overweight and insulin resistance women. Funding Sources Food Research Center (FoRC), Sao Paulo Research Foundation (FAPESP).