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Establishment and characterisation of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies

D Strüder,T Momper,N Irmscher,J Liese,S Schraven,A Zimpfer,B Frerich,C Junghanss,R Mlynski,C Maletzki

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., BonnLaryngo-Rhino-Otologie（2021）

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Abstract
Head and neck cancer exhibits considerable heterogeneity in biologic behaviour and therapeutic response. Patient-derived xenografts (PDX) maintain morphology and molecular profiling of the original tumours, thus providing a platform for the examination of disease biology and novel therapeutic agents.
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Key words
neck cancer models,neck cancer,head,surgical specimens,patient-derived
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