Wnt/β-catenin inhibitor ICG-001 enhances the antitumor efficacy of radiotherapy by increasing radiation-induced DNA damage and improving tumor immune microenvironment in hepatocellular carcinoma

Yan Huang,Hailong Sheng,Yazhi Xiao,Wei Hu,Zhihong Zhang,Yiyao Chen,Zhenru Zhu,Dehua Wu,Chuanhui Cao,Jingyuan Sun

Radiotherapy and Oncology（2021）

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摘要

•ICG-001 increases intrinsic radiosensitivity and activates radiation-regulated TIME of HCC.•ICG-001 improves radiation-regulated TIME by enhancing cGAS/STING pathway activation.•ICG-001 increases RT effects in tumor control, survival prolong, and recurrence prevention.•ICG-001 might be a synergetic treatment for radioimmunotherapy in HCC patients.

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关键词

Hepatocellular carcinoma,Wnt/β-catenin inhibitor,Radiotherapy,Radioresistance,Tumor immune microenvironment,cGAS/STING

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