Is the Wistar Rat a more Suitable Normotensive Control for SHR to Test Blood Pressure and Cardiac Structure and Function?

Leonardo Mateus Teixeira de Rezende,Leôncio Lopes Soares,Filipe Rios Drummond, Pedro Zavagli Suarez,Luciano Leite,Joel Alves Rodrigues,Tiago Leal,Lukiya Favarato,Emily Correna Carlo Reis,Evandro Favarato, Miguel Carneiro,Antônio José Natali,Cândido Coimbra,Thales Prímola Gomes

International Journal of Cardiovascular Sciences（2021）

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摘要

Background: There are divergences in the literature regarding the experimental model (Wistar-WIS or Wistar Kyoto-WKY) to be used as a Spontaneously Hypertensive Rat (SHR) control. The characterization of these models in terms of cardiovascular parameters provides researchers with important tools at the time of selection and application in scientific research. Objective: The aim of this study was to evaluate the use of WIS and WKY as a Spontaneously Hypertensive Rat (SHR) control by assessing the long-term behavior of blood [...]

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wistar rat,blood pressure,suitable normotensive control,cardiac structure

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