An Analysis of Circulating Betatrophin Levels in Relation with Type1 and Type2 Diabetes Mellitu Running Title: Betatrophin and Diabetes

Background: Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Previous researches of betatrophin on glucose and lipid metabolism were mainly done under insulin resistant conditions. Only three studies from two centers investigated the association between betatrophin and type1 diabetes mellitus (T1DM). There is no consensus about the association of diabetes and betatrophin levels. Main purpose of this study was to investigate the relationship between betatrophin and various markers affecting glucose and lipid metabolisms in T1DM, type 2 diabetes mellitus (T2DM) and control subjects. Methods: T1DM (n: 64), T2DM (n: 67) and control subject (n: 31) enrolled in this study. All subjects' physical examination, measurements of antropometric parameters and blood pressures were documented. Insulin, C-peptide, HbAIc, triglyceride, LDL-C, HDL-C, CRP, microalbuminuria, and betatrophin levels were measured in all groups. Results: Serum betatrophin levels were significantly increased in patients with T1DM (p: 0.0001). Betatrophin was correlated with LDL-C in T1DM (r: 0.265, p: 0.034). No relationship between betatrophin and glucose metabolism (FBG, HbA1c) in T1DM was observed. Serum betatrophin levels were not increased in T2DM patients. Further more, we observed a significant positive correlation between betatrophin and FBG (r: 0.289, p: 0.019) and HbA1c (r: 0.372, p: 0.002) in T2DM. As distinct from previous studies we did not find any relationships between betatrophin and insulin resistance in any groups. Conclusions: Betatrophin is significantly higher in T1DM. Betatrophin levels correlated positively with markers of glycemic control in T2DM. Circulating betatrophin levels appeared to be the metabolic parameters of the T2DM rather than T1DM.