Effect of Allanblackia floribunda stem bark aqueous extract in male albino wistar rats: androgenic activities and penile nitric oxide (NO) production

Objective: Covid-19 like pandemics is encouraging the plant based medicines nowadays.The Allanblackia floribunda (Clusiaceae) stem bark extract is used to treat the sexual dysfunctions problems in Cameroon traditionally.The reported oral studies research in adult male rats using the bark extract for eight days revealed the increased frequencies of erection, intromission and prolonged latency of ejaculation, while intravenous and oral administration delayed the occurrence of ejaculation in spinal male rats.The present study aimed to investigating the androgenic, androgen releasing property of aqueous extract of stem bark and its relation with corporal nitric oxide (NO) A. floribunda production in male albino adult Wistar rats.: This extended work was done to investigate the Materials and methods androgenic and androgen releasing tendency of stem bark aqueous extract in male albino Wistar rats A. floribunda through assessment of the corporal nitric oxide, testosterone, LH production, reproductive organs weight and accessory reproductive organs secretions.: Treatment of animals with extract at the dose 150 mg/kg ResultsA. floribunda increased serum testosterone and luteinizing hormone.In testis homogenate, it increased testosterone and cholesterol levels, while enhancing penile nitrites and vesicular fructose.Moreover, animals treated with extract A. floribunda displayed high red blood cells number, hematocrit level, thickness and diameter of the seminiferous tubules. Conclusion:improves the male reproductive of male rats through its androgenic properties and A. floribunda improvement of biomarkers of accessory reproductive organs.