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Regulation of telomere homeostasis and genomic stability in cancer by N 6 -adenosine methylation (m 6 A)

Ji Hoon Lee,Juyeong Hong,Zhao Zhang,Bárbara de la Peña Avalos,Cecilia J. Proietti,Agustina Roldán Deamicis,Pablo Guzmán G.,Hung-Ming Lam,Jose Garcia,Martine P. Roudier,Anthony E. Sisk,Richard De La Rosa, Kevin Vu,Mei Yang,Yiji Liao,Jessica Scheirer,Douglas Pechacek,Pooja Yadav,Manjeet K. Rao,Siyuan Zheng,Teresa L. Johnson-Pais,Robin J. Leach,Patricia V. Elizalde,Eloïse Dray,Kexin Xu

Science Advances（2021）

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Abstract
Down-regulation of HMBOX1 via METTL3-catalyzed m 6 A causes genomic instability driven by telomere dysfunction in cancer.
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