Mucinous Differentiation Is Predictive Of Improved Outcomes In Low-Grade Endometrioid Carcinoma

Objective: Endometrial carcinoma (EC) is the most common gynecological malignancy. Endometrioid carcinoma (EEC), the most common subtype, accounts for 75% of the cases and is often associated with squamous or mucinous differentiation. While the prognosis of pure mucinous carcinoma has been previously studied, the significance of mucinous differentiation in EEC is yet to be determined. The aim of this study was to correlate the presence of mucinous differentiation with clinicopathological features of a large multiinstitutional cohort of low-grade EEC (LGEEC) and to evaluate its impact on clinical outcomes.