Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes (Adv. Sci. 16/2021)

New Therapeutic Options for the Treatment of Diabetes In article number 2100536, Huating Li, Gianni Panagiotou, Weiping Jia, and co-workers demonstrate lean patients with type 2 diabetes have distinct gut microbiota and bile acid profiles. The “Magician” Akkermansia muciniphila connects the gut to pancreas and liver by modulating 3β-chenodeoxycholic acid and fibroblast growth factor 19, which sheds light on new therapeutic options for the prevention or treatment of diabetes.