Modulation of proinflammatory bacteria- and lipid – coupled intracellular signaling pathways by commensal Bifidobacterium animalis R101-8
48. Jahrestagung der Gesellschaft für Gastroenterologie in Bayern e.V. Information und Programm: www.gfgb.orgZeitschrift für Gastroenterologie(2021)
Abstract
Background and aims Following a high-fat diet, changes in gut microbiota contribute to increased gut permeability, metabolic endotoxemia, and low grade inflammation-induced metabolic disorders. To better understand whether commensal bifidobacteria influence the expression of key metaflammation-related biomarkers (chemerin, MCP-1, PEDF) and modulate the pro-inflammatory bacteria- and lipid – coupled intracellular signaling pathways we aimed at i) investigating the influence of the establishment of microbial signaling molecules-based cell-cell contacts on the involved intercellular communication between enterocytes, immune cells and adipocytes, and ii) assessing their inflammatory mediators’ expression profile within an inflamed adipose tissue model.
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Key words
signaling pathways,proinflammatory
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