Synthesis and Biological Properties of New Piperidine Substituted Benzothiazole Derivatives

In present work, ethyl 2-aminobenzo[d]thiazole-6-carboxylate was reacted to piperidine using copper(II) bromide to get ethyl 2-(piperidin-1-yl)benzo[d]thiazole-6-carboxylate. The reaction of ethyl 2-(piperidin- 1-yl)benzo[d]thiazole-6-carboxylate with NaOH produces 2-(piperidin-1-yl)benzo[d]thiazole-6- carboxylic acid. The inter-mediate 2-(piperidin-1-yl)benzo[d]thiazole-6-carboxylic acid have been isolated as stable compounds. The chemical structures of synthesized compounds were established based on the 1H & 13C NMR and IR spectral data. The mass of the novel compounds was established with the help of the LC-MS technique. The photoluminescence spectra explain the optical property of the compound. The biological studies of synthesized compounds show that the compound 5e possesses good antibacterial activity and compound 5d has good antifungal activity.