Fetuin A and abdominal aorta calcification in hemodialysis patients

Abstract Background Patients with chronic kidney disease (CKD), especially those on regular hemodialysis, have unique Mineral and endocrine disturbances. Vascular calcification is a dynamic process influenced by bone kidney disease, as well as an imbalance between promoters and inhibitors of extra-osseous bone formation. Calcification is defined as the accumulation of calcium salts in tissues. This is a specific type of mineralization, which in contrast to calcification involves the deposition of any mineral. Aim of the work To determine abdominal blood vessels calcification in hemodialysis patients and its relation to fetuin A plasma level. Patients and Methods This study included 60 patients (30 case and 30 control) admitted to Mansoura university hospitals. The patients were included in this study, all are End-stage renal disease (ESRD) patients on regular hemodialysis (HD) (4 Hours- 3 times weekly) for at least 3 month after obtaining informed conset from all patients). Results Our study showed non significant negative correlation between fetuin A and aortic calcium score . Conclusion High serum fetuin-A level was shown to be protective factor against vascular calcification and is associated with lower severity of abdominal aortic calcifications in regular hemodialysis patients.