301 Diagnostics and treatment of childhood malignant liver tumors – a single center experience

We report our center experience in medical management of malignant childhood liver tumors Retrospective review of hospital medical data basis In the period of 19 years 13 patients were diagnosed and treated in our institution due to malignant liver tumor (8 males and 5 females). Average age at diagnosis was 4,04 years. 3 of them were born prematurely. Histopathological type of the tumor corresponded to hepatoblastoma in all cases, except one which is the case of hepatocellular carcinoma. The most frequent PRETEXT group was stage 2. Radiological imagaing and biopsy were important in making the correct diagnosis. The usual medical management consisted of neoadjuvant chemotherapy and surgical procedure followed by adjuvant chemotherapy. Overall survival is 76,9% and the average follow-up period 71,1 months. Malignant childhood liver tumors are challenging to manage necessitating multidisciplinary approach and collaboration.