A kit-based aluminium-[¹⁸F]fluoride approach to radiolabelled microbubbles

Jin Hui Teh,Marta Braga,Louis Allott,Chris Barnes,Javier Hernández-Gil,Meng-Xing Tang,Eric O. Aboagye, Nicholas J. Long

Chemical Communications（2021）

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摘要

A facile, kit-based method for 18F-labelling of ultrasound microbubble contrast agents is reported using the IEDDA ligation between a trans-cyclooctene modified phospholipid and a [18F]AlF-tetrazine tracer, enabling in vivo tracking of microbubbles.

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A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles

A kit-based aluminium-[¹⁸F]fluoride approach to radiolabelled microbubbles