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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation

Feng Gu,Aileen Krüger,Hannes G. Roggenkamp, Rick Alpers,Dmitri Lodygin,Vincent Jaquet,Franziska Möckl,Lola C. Hernandez C., Kai Winterberg,Andreas Bauche,Anette Rosche,Helmut Grasberger,John Y. Kao,Daniel Schetelig,René Werner,Katrin Schröder,Michael Carty,Andrew G. Bowie,Samuel Huber,Chris Meier,Hans-Willi Mittrücker,Joerg Heeren,Karl-Heinz Krause,Alexander Flügel,Björn-Philipp Diercks,Andreas H. Guse

Science Signaling（2021）

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Abstract
The enzymes DUOX1 and DUOX2 may mediate rapid and then sustained NAADP production to promote Ca 2+ signaling in T cells.
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