Electron Density of Paracetamol Metastable Polymorph, Topologycal H-Bonds Analysis

The experimental electron density of paracetamol metastable polymorph (orthorhombic, Pbca) was derived from highresolution X-ray diffraction at 100 K. The multipole model was used to refine electron density and for experimental analysis of the features of the critical points for orthorhombic modification. Geometrical H-bonds features were obtained from spherical and multipole models. The current study provides topological H-bonds analysis in orthorhombic paracetamol compared with stable monoclinic paracetamol polymorphs in normal conditions