Effectoftail-suspensiononlevelsofpro- andanti-inflammatory cytokins and morphological changes in rat's pulmonary tissues

Cytokin regulation of local immune reactions in pulmonary tissues (IL-10, IL-4, TGFb1, TNFα), and morphology of the vascular bed and alveolar epithelium of the lung air compartments were studied in a 15-day tail-suspended Wistar male rats with a body mass of 180–200 grams. Cytokin regulation of the local immunity after suspension was characterized by activation of cell proliferation and differentiation regulator TGFβ1 aimed to forestall the inflammatory and auto immune processes and to promote remodeling of the lung epithelial structure and extracellular matrix.