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Circular Rims2 Deficiency Causes Retinal Degeneration (Adv. Biology 12/2021)

Lan‐Fang Sun,Yue Ma,Yang‐Yang Ji,Zhen Wu,Ya‐Han Wang,Hao Mou,Zi‐Bing Jin

Advanced Biology（2021）

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Abstract
Circular Rims2 Deficiency In article 2100906, Jin and co-workers discover that a circular RNA, circRims2, is crucial for retinal maintenance and function. Targeted silence of circRims2, but not linear Rims2, leads to significant damages of retinal neurons in the retina. Furthermore, retinal cell apoptosis is mediated by the tumor necrosis factor signaling pathway.
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Key words
deficiency,degeneration
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