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Jianpi Huayu Decoction Enhances the Effect of Sorafenib and Alleviates Adverse Events in Hepatocellular Carcinoma by Remodeling the Gut Microbiota

Xue Deng,Yingjie Xie,Yantong Lu,Xueyan Li,Xuan Guo,Xuhui Huang,Xiaohe Lan,Juze Lin,Wei Tan,Changjun Wang

SSRN Electronic Journal（2021）

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Abstract
•JHD enhanced the therapeutic effect of sorafenib and alleviated the adverse effect of sorafenib.•JHD protected sorafenib-induced increasing pro-inflammatory microbiota and led to downregulation of IL-6/STAT3 inflammation signaling.•The combination of JHD and sorafenib provided a promising treatment for advanced HCC.
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Key words
Hepatocellular carcinoma,Jianpi Huayu,Decoction,Sorafenib,Microbiota
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