Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu _{2− x} Se Nanoparticles to Enhance Anti‐Tumor Immunity (Adv. Funct. Mater. 12/2022)

Reprogramming Tumor-Associated Macrophages In article number 2108971, Zhen Li and co-workers find that ultra-small Cu2−xSe nanoparticles can effectively polarize tumor-associated macrophages (TAMs) from the tumor-supportive M2 phenotype into anti-tumor M1 phenotype to significantly boost anti-tumor immunity through a novel mechanism. The nanoparticles can generate reactive oxygen species to trigger polarization through the novel ROS-TRAF6-IRF5-IL-23 signaling pathway, rather than the classic ROS-NF-?B-iNOS pathway.