Dephosphorylation of GABA<sub>B</sub> receptor subunit by over-expression of protein phosphatase 5.

Kyosuke Uno, Takuro Yoshinaga,Kosuke Kawarai,Toshihiko Kinjo,Nobuyuki Kuramoto

Proceedings for Annual Meeting of The Japanese Pharmacological Society（2022）

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摘要

[Purpose] GABAB receptors are responsible for inhibitory transmission by conjugating with Gi proteins. In addition, this receptor functions by forming a dimer of R1 and R2 subunits (R2). Phosphorylation of serine residue at position 892 (S892) of R2 suppresses receptor internalization and desensitization. We have investigated the possibility that protein phosphatase 5 (PP5) dephosphorylates S892. In this study, we investigated the effect of overexpression of PP5 on the phosphorylation level of S892.

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protein phosphatase,receptor subunit,over-expression

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Dephosphorylation of GABA&lt;sub&gt;B&lt;/sub&gt; receptor subunit by over-expression of protein phosphatase 5.

Dephosphorylation of GABA<sub>B</sub> receptor subunit by over-expression of protein phosphatase 5.