Mp11-09 survival analysis among utah residents with spina bifida born between 1950 and 2015

You have accessJournal of UrologyCME1 May 2022MP11-09 SURVIVAL ANALYSIS AMONG UTAH RESIDENTS WITH SPINA BIFIDA BORN BETWEEN 1950 AND 2015 Cynthia Sharadin, Suzanne Lange, J.J. Horns, Chad Wallis, Glen Lau, and Anthony Schaeffer Cynthia SharadinCynthia Sharadin More articles by this author , Suzanne LangeSuzanne Lange More articles by this author , J.J. HornsJ.J. Horns More articles by this author , Chad WallisChad Wallis More articles by this author , Glen LauGlen Lau More articles by this author , and Anthony SchaefferAnthony Schaeffer More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002533.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Life expectancy for people with spina bifida (PSB) is believed to have increased over the last 50 years. This study compares the risk of death between PSB and controls and assesses whether survival among PSB has changed between 1950 and 2015. METHODS: Study design: case control. Data source: Utah Population Database (UPDB) – merges data from birth and death records, the state’s two major health systems, and other sources; captures over 85% of Utahns. Cases: SB listed on birth certificate or SB ICD9 code(s) appearing in the medical record; born between 1/1950 and 12/2015. Controls: 10:1 matching on gender, county at and year of birth. Statistics: Cox proportional hazards models to 1a) compare risk of death between PSB and controls and 1b) test whether risk of death differed between birth decades within the SB population only. Kaplan-Meier (K-M) curves depict each survival function. RESULTS: The study includes 942 cases and 9420 controls (Table 1). 270 (29%) cases died. After controlling for gender and county, PSB were found to have a 17-fold increased risk of death compared to controls (HR 16.9, 95% CI [14.1,20.1]; Figure 1a) irrespective of birth decade.When comparing the risk of death among PSB, after controlling for gender and county, PSB born in the 1970s and 1990s had a 55% (HR 0.45, 95% CI [0.31,0.66]) and 84% (HR 0.16, 95% CI [0.10,0.27]) decreased risk of death, respectively, relative to PSB born in the 1950s. There was no difference in risk of death between genders or when considering county. The K-M curve shows that infant mortality decreased substantially starting in the 1980s, and the proportion of PSB living through their 30th birthday increased substantially over time (from ∼30% if born in the 1950s to ∼85% if born in the 1980s or -90s) (Figure 1b). CONCLUSIONS: There have been major improvements in infant mortality and overall life expectancy for PSB in Utah over the last 70 years. This could be due to improvements in prenatal detection or neonatal intensive care, or developments in neurosurgical, urologic, and other medical care. Source of Funding: Dr. Schaeffer is supported by K08DK119535 © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e160 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Cynthia Sharadin More articles by this author Suzanne Lange More articles by this author J.J. Horns More articles by this author Chad Wallis More articles by this author Glen Lau More articles by this author Anthony Schaeffer More articles by this author Expand All Advertisement PDF downloadLoading ...