Mp28-10 10-year outcomes in work loss, physical function, and mental health of 6,693 men undergoing primary treatment for prostate cancer

You have accessJournal of UrologyCME1 May 2022MP28-10 10-YEAR OUTCOMES IN WORK LOSS, PHYSICAL FUNCTION, AND MENTAL HEALTH OF 6,693 MEN UNDERGOING PRIMARY TREATMENT FOR PROSTATE CANCER Samuel Washington, Peter Lonergan, Janet Cowan, Shoujun Zhao, Scott Greenberg, Jenny Broering, Nynikka Palmer, Robert Parker, Alexander Bell, Matthew Cooperberg, and Peter Carroll Samuel WashingtonSamuel Washington More articles by this author , Peter LonerganPeter Lonergan More articles by this author , Janet CowanJanet Cowan More articles by this author , Shoujun ZhaoShoujun Zhao More articles by this author , Scott GreenbergScott Greenberg More articles by this author , Jenny BroeringJenny Broering More articles by this author , Nynikka PalmerNynikka Palmer More articles by this author , Robert ParkerRobert Parker More articles by this author , Alexander BellAlexander Bell More articles by this author , Matthew CooperbergMatthew Cooperberg More articles by this author , and Peter CarrollPeter Carroll More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002571.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Men with prostate cancer (PCa) often consider their work (time off) and health when choosing between management options. Using the CaPSURE database, we examine associations between PCa treatment and work loss, physical function, and mental health within ten years of initial management. METHODS: We identified men with PCa managed with radical prostatectomy (RP), external beam radiation therapy (EBRT), brachytherapy (BT), or active surveillance/watchful waiting (AS/WW), in a longitudinal study of 43 primarily community-based US urology practices. Data on work type [full-time, part-time, or retired/unemployed/disabled)], physical labor (PL, y/n), weeks of work missed, number of clinic visits annually, physical function (PF) and mental health (MH) were collected prior to treatment and 1,3,5 and 10 years after treatment. We examined associations between treatment and work weeks missed, PF, and MH using repeated measures GEE and generalized linear mixed modeling adjusted for clinical, health behaviors, and demographics. Estimates were reported as relative risk (RR) and 95% confidence intervals or slope and standard error (SE). A p<0.05 was significant. RESULTS: We identified 6,673 men, with mean age at diagnosis of 64.4 years (SD 8.3). Most were insured (54% private, 43% Medicare), white (90%, 7% Black, 1% Latino) with low- (60%) or intermediate-risk (32%) disease by CAPRA score. Most had paid work (44%) or were retired (45%) and underwent RP (62%, 14% BT, 14% EBRT, 10% AS/WW). Men missed median 5.3 weeks in first year (IQR 1.6-12.2) with up to 2.1 weeks missed at all other time points. Full-time work (RR 1.5, 95% 1.34-1.64), part time work (RR 1.19, CI 1.03-1.38), and PL (RR 1.17, 95% CI 1.05-1.30) conferred greater risk of long-term work loss. Full time (slope +17.7, SE 0.7) and part time work (slope +8.9, SE 0.9) maintained long-term PF. Treatment was not associated with long term work loss or changes in PF. MH was maintained with full time (slope +1.7, SE 0.5) and part time work (slope +2.3, SE 0.6). AS/WW (slope +1.5, SE 0.7) maintained MH while declining with BT (slope -0.8, SE 0.6) and EBRT (slope -0.9, SE 0.6). CONCLUSIONS: Most men undergoing PCa treatment for PCa continued to miss work due to cancer care for years after treatment. Employment maintained MH and PF over time. Compared to RP, AS/WW maintained long-term MH scores while BT and RT noted declines over time. When counseling men, long-term impact of PCa treatment on work and health should be carefully discussed thoroughly. Source of Funding: UCSF Goldberg-Benioff Program in Translational Cancer Biology © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e464 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Samuel Washington More articles by this author Peter Lonergan More articles by this author Janet Cowan More articles by this author Shoujun Zhao More articles by this author Scott Greenberg More articles by this author Jenny Broering More articles by this author Nynikka Palmer More articles by this author Robert Parker More articles by this author Alexander Bell More articles by this author Matthew Cooperberg More articles by this author Peter Carroll More articles by this author Expand All Advertisement PDF DownloadLoading ...