The systemic immune-inflammation index (sii) as predictor factor of survival in patients undergoing radical nephroureterectomy for upper tract urothelial carcinoma

You have accessJournal of UrologyCME1 May 2022MP40-09 THE SYSTEMIC IMMUNE–INFLAMMATION INDEX (SII) AS PREDICTOR FACTOR OF SURVIVAL IN PATIENTS UNDERGOING RADICAL NEPHROURETERECTOMY FOR UPPER TRACT UROTHELIAL CARCINOMA Skander Zouari, Saadi Ahmed, Setti Boubaker Nouha, Bilel Saidani, Marouene Chakroun, Khadija Medddeb, Mouna Ayadi, Meriem Ksontini, Ahlem Blel, Hamza Boussaffa, Abderrazek Bouzouita, Amine Derouiche, Riadh Ben Slama, Ksontini Feriel, Amel Mezlini, Soumaya Rammeh, Haroun Ayed, and Mohamed Chebil Skander ZouariSkander Zouari More articles by this author , Saadi AhmedSaadi Ahmed More articles by this author , Setti Boubaker NouhaSetti Boubaker Nouha More articles by this author , Bilel SaidaniBilel Saidani More articles by this author , Marouene ChakrounMarouene Chakroun More articles by this author , Khadija MedddebKhadija Medddeb More articles by this author , Mouna AyadiMouna Ayadi More articles by this author , Meriem KsontiniMeriem Ksontini More articles by this author , Ahlem BlelAhlem Blel More articles by this author , Hamza BoussaffaHamza Boussaffa More articles by this author , Abderrazek BouzouitaAbderrazek Bouzouita More articles by this author , Amine DerouicheAmine Derouiche More articles by this author , Riadh Ben SlamaRiadh Ben Slama More articles by this author , Ksontini FerielKsontini Feriel More articles by this author , Amel MezliniAmel Mezlini More articles by this author , Soumaya RammehSoumaya Rammeh More articles by this author , Haroun AyedHaroun Ayed More articles by this author , and Mohamed ChebilMohamed Chebil More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002600.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The systemic immune–infammation index (SII) is an immunological and inflammatory index obtained from the pre-operative leukocyte formulas and based on the count of lymphocytes, neutrophils and platelets. The aim of this study is to assess the prognostic value of SII in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). METHODS: Between 1989 and December 2020, 193 patients underwent RNU for UTUC. Metastatic patients at first presentation, patients with lack of follow up or with missing data were excluded. Calculation of SII is based on the formula: number of neutrophils*platelets/lymphocytes. Patients were stratified into two groups defined on the basis of an SII threshold value obtained from the ROC curve plotting by the XLSTAT software. Correlation of SII to clinical parameters of prognostic interest was made by the student test, the Khi2 test and the Mann Whitney test. The survival curves were obtained using the Kaplan-Meier method (IBM®SPSS®23.0). RESULTS: A total of 107 patients were included. Mean age was 66.6 years. Cut-off value for SII in our population was 668. Forty-nine patients were in Group 1 (SII <668) while 58 patients were in Group 2 (SII >668). Main clinical and pathology features are summarized in Table 1. SII >668 was correlated with high histological grade (p=0.009), presence of vascular emboli (p=0.012), advanced TNM stage (p=0.000) and positive surgical margins (p=0.002). Average follow-up was 25.67 months. SII >675 was associated with overall survival (p=0.006) (Figure 1), metastasis (p=0.047) and locoregional recurrence (p=0.034), but not with local recurrence (p=0.082) or intravesical recurrence (p=0.829). CONCLUSIONS: High preoperative SII is significantly associated with higher histological grade, advanced tumor stage and worse survival outcomes in patients operated by RNU for UTUC. It could be a potentially useful pre-operative prognostic tool to identify patients with aggressive tumors and guide decision making strategy. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e677 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Skander Zouari More articles by this author Saadi Ahmed More articles by this author Setti Boubaker Nouha More articles by this author Bilel Saidani More articles by this author Marouene Chakroun More articles by this author Khadija Medddeb More articles by this author Mouna Ayadi More articles by this author Meriem Ksontini More articles by this author Ahlem Blel More articles by this author Hamza Boussaffa More articles by this author Abderrazek Bouzouita More articles by this author Amine Derouiche More articles by this author Riadh Ben Slama More articles by this author Ksontini Feriel More articles by this author Amel Mezlini More articles by this author Soumaya Rammeh More articles by this author Haroun Ayed More articles by this author Mohamed Chebil More articles by this author Expand All Advertisement PDF downloadLoading ...