EFFECT OF GENTABIFERON-B ON THE FUNCTIONAL STATUS OF KIDNEYS IN SUBACUTE EXPERIMENT

The article presents data on the study of the effect of gentabiferon-B on the functional status of kidneys in white rat males with prolonged administration of the drug for 21 days. It was found that the administration of gentabiferon-B at doses of 1/50 and 1/20 LD50 did not have a significant effect on renal function in terms of spontaneous and induced diuresis, urea and creatinine concentrations, and no significant changes were revealed by pathomorphological examination. In rats, after a course of gentabiferon-B administration at a dose of 1/10 LD50, according to the above mentioned indicators, there were registered significant changes relative to the control group. However, all of them were reversible, which was confirmed by the results of studies 10 days after the drug withdrawal.