The Effect of Controlled Mixing on ROY Polymorphism

Proceedings of The 3rd International Online Conference on Crystals(2022)

引用 1|浏览18
暂无评分
摘要
We report the investigation of various experimental conditions and their influence on polymorphism of 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile, commonly known as ROY. These conditions include an in-house-developed microfluidic chip with controlled mixing of parallel flows. We observed that different ROY concentrations and different solvent to antisolvent ratios naturally favored different polymorphs. Nonetheless, identical samples prepared with different mixing methods, such as rotation and magnetic stirring, consistently led to the formation of different polymorphs. A fourth parameter, namely the confinement of the sample, was also considered. Untangling all those parameters and their influences on polymorphism called for an experimental setup allowing all four to be controlled accurately. To that end, we developed a novel customized microfluidic setup allowing reproducible and controlled mixing conditions. Two parallel flows of antisolvent and ROY dissolved in solvent were infused into a transparent microchannel. Next, slow and progressive mixing could be obtained by molecular diffusion. Additionally, the microfluidic chip was equipped with a piezoceramic element, allowing the implementation of various mixing rates by acoustic mixing. With this device, we demonstrated the importance of parameters other than concentration on the polymorphism of ROY.
更多
查看译文
关键词
ROY,polymorphism,microfluidics,acoustic mixing,diffusive mixing
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要