P272. Diminished ‘Punishment Learning’ in Patients with Treatment-Resistant Depression

Human neuroimaging studies demonstrate diminished reward learning in dopaminergic regions known to encode prediction errors between expected and experienced rewards in patients with depression. However, differences in punishment learning and how these may vary in patients responsive or not to antidepressants is unclear. We utilized a novel valence-partitioned reinforcement learning model to examine cohort-specific differences in punishment learning.