P37. Effects of Abstinence During Treatment on Shared Nucleus Accumbens Reactivity and Craving in Response to a Drug-Related Movie in Heroin Addiction

Greg Kronberg,Ahmet O. Ceceli,Yuefeng Huang,Pierre-Olivier Gaudreault,Natalie McClain,Devarshi Vasa,Pias Malaker,Defne Ekin,Nelly Alia-Klein,Rita Z. Goldstein

Biological Psychiatry（2022）

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摘要

Drug addiction is associated with heightened mesolimbic cortico-striatal reactivity to drug-related stimuli over alternative reinforcers. However, the extent of this biased processing in real-world settings, its relationship to craving, and its dynamics with abstinence and treatment are not fully established, especially in opioid addiction.

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关键词

Addiction,Opioid Use Disorder,Naturalistic,Craving,Cue-Reactivity

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