DISTRIBUTION CHARACTERISTICS OF PATHOGENIC BACTERIA AND ITS EFFECTS ON CARDIOPULMONARY FUNCTION IN ELDERLY PATIENTS WITH HEART FAILURE COMPLICATED WITH PULMONARY INFECTION

Objective: The objective is to study the distribution characteristics of pathogenic bacteria and its effects on cardiopulmonary function in elderly patients with heart failure complicated with pulmonary infection. Methods: Eighty patients with senile heart failure complicated with pulmonary infection admitted to our hospital from January 2016 to December 2017 were selected as the infection group, and 78 patients with senile heart failure without infection were enrolled in the uninfected group. Another 76 normal elderly people who underwent a physical examination were set as the control group. The distribution of pathogenic bacteria in elderly patients with heart failure complicated with pulmonary infection was analysed. The cardiopulmonary function indices and level of serum interleukin-6(IL-6), C-reactive protein levels (CRP), and tumour necrosis factor-alpha (TNF-alpha) in the three groups were compared. The relationship between the inflammatory factor expression level and cardiopulmonary function index was analysed via the Pearson test. Results: Among the 80 infected patients, 121 pathogenic bacteria were isolated, of which 86 were Gram-negative bacteria, accounting for 71.07%; 25 were Gram-positive bacteria, accounting for 20.66%; and 10 were fungi, accounting for 8.26%. The difference in the cardiopulmonary function index between the infected and uninfected groups was statistically significant compared with the control group (P<0.05). The levels of serum IL-6, CRP, and TNF-alpha in the infected group and uninfected group were higher than those in the control group (P<0.05), and the levels in the infected group were higher than those in the uninfected group (P<0.05). Correlation test results showed that L-6, CRP, and TNF-alpha were positively correlated with FEV1, FVC, FEV1/FVC, DLCO, MMEF, LVEF, LVEDD, and LVESD (P<0.05). Conclusion: The pathogenic bacteria of elderly patients with heart failure complicated with pulmonary infection that can cause damage to the patient's cardiopulmonary function are mainly Gram-negative bacteria.