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长链非编码RNA牛磺酸上调基因1通过激活TGF-β1/Smad信号通路发挥促大鼠肝纤维化的作用

Chinese Journal of Immunology(2020)

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Abstract
肝纤维化属于可逆性病变,是进一步发展为肝硬化的关键环节,也是慢性肝病共同的病理特征.肝纤维化的特征为细胞外基质(尤其是胶原)在肝脏内的大量沉积.肝星状细胞的活化在肝纤维化的发生过程中发挥关键作用,活化的肝星状细胞可分泌α-SMA、collagenⅠ、TIMP-1 等[1,2].
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